Undergraduate courses

Postgraduate courses (will be added soon)
 

Undergraduate courses:

1.Organic Chemistry:

Code: 132/6
Credit hours (2+1)
Position: Prepharmacy, Second Semester
I- Lectures: (2 hours lecture /week, for 15 weeks)
I) INTRODUCTION (8 Hours)
- The development of organic chemistry, as a science.
- Chemical bonds.
- Shapes of molecules.
- Polar and non polar molecules.
- Orbital hybridization.
- Isomerism.
- Types of reactions.
- Classification of organic compounds.
- Nucleophilicity and basicity.
- Some philosophical observations.
II) CLASSES OF ALIPHATIC COMPOUNDS (22 Hours)
The Study includes: Nomenculature, Synthesis,
Physical Properties and Chemical Reactions of:
- Alkanes.
- Alkenes.
- Polyenes.
- Halogen compounds.
- Alcohols.
- Thio alcohols.
- Ethers.
- Thio ethers.
- Aldehydes and ketones.
- Carboxylic acids.
- Derivatives of carboxylic acids at the alkyl group.
- Poly carboxylic acids.
- Unsaturated dicarboxylic acids.
- Amines.
II- Practical Part (3 hours section /week, for 15 weeks):
Detection of elements (N, C, S, Cl, Br, I, F) (6hr)
Identification of organic and inorganic compounds (3hr)
Determination of melting point (3hr)
Determination of melting point (3hr)
Determination of solubility, of unknown organic compounds in different aqueous and organic solvents (3hr).
Classification of compounds according to solubility (3hr)
Identification of Liquid organic compounds (9)
Identification of solid organic compounds (15)




2.Pharmaceutical Organic Chemistry
Code: 211/6
Credit hours (2+1)
Position: First year, First Semester
I- Lectures: (2 hours lecture /week, for 15 weeks)
1) Aromaticity: (4hr)
I-Resonance theory,M.O theory (Frosti-polygone to construct M.O), Huckel’s rule. ii-Annulenes and Aromatic ions.
2) Nomenclature of benzenoid compounds.
3) Reactions of Benzene;Electrophilic Substitution ; Nitration, halogenation, sulphonation, FC alkylation and acylation ). (8hr)
Scope, & limitations and MECHANISM of the reactions of Benzenoid compounds and their pharmaceutical applications.
4) Alkyl benzene and aralkyl benzene, Scope, limitations of their reactions and their pharmaceutical applications. (2hr)
5) Orientation of electrophilic reactions for mono and disubstituted benzene. Effect of substituents on the reactivity. (4hr)
6) Aryl and aralkyl halides. Scopes, Limitations of their reactions and preparation and their pharmaceutical applications. (4hr)
7) Aromatic nucleophilic substitutions, (Activated and Non- activated mechanisms ) Factor which increase or decrease reactivity. (4hr)
8) Aromatic Nitro- Compounds. Nitrating agents, Scope, limitations of their reactions during ES and SN reactions. Preparations and their pharmaceutical and industrial Applications: Charge transfer complex. Reduction in Different media. (4hr)
9) Aromatic and aliphatic amines: Noemculature, synthesis, reactions, interconversions. (6hr)
10) Aromatic Diazonium salts: Synthesis, Reactions, used in conversions in aromatic compounds. (4hr)
II- Practical Part (3 hours section /week, for 15 weeks):
-Condition , solubility , & Dry heat test
-Chemical tests.
-Alcohols: Method , Ethanol, lsopropanol, Benzyl alcohol, & Glycerol
-Aldehydes & ketenes: Acetaldehyde, Formaldehyde, Benzaldehyde, & Acetone
-Phenols: Phenol, Resorcinol, a-& β--Menthol, & Cresols.
-Aliphatic acids: Acetic, Formic & lactic acids
-Aliphatic acids (cont.): Oxalic, Citric, & Tartaric acids
-Aromatic acids: Benzoic, Phallic, & Salicylic acids
-Salts of carboxylic acids: Sodium, Potassium , & Ammonium salts,
-Fatty acids: Satiric & Oleic acids - Acid anhydrides: Phallic anhydride



3.Pharmaceutical Organic Chemistry
Code: 252/6
Credit hours (3+1)
Position: First year, Second Semester
I- Lectures: (2 hours lecture /week, for 15 weeks)
A-Aromatic compounds (Cont.):
1-Phenols: (4hr)
i-acidity
ii-reactions of the OH and SH.
iii-Reactions of the benzene ring.
iv-Protection and deprotection of OH
v-examples of pharmaceutical products.
2-Sulphonic acids and sulphonamides: (4hr)
i-acidity.
ii-Reactions of the SO3H group and the aromatic ring.
iii-Uses in protection reactions.
iv-Examples of pharmaceutical products.
v-Sulphonamides and sulpha Drugs and their uses in
pharmacy
3-Aldehydes and ketones. Scope, limitations of their reactions and their pharmaceutical applications. (6h).
4-Aromatic Carboxylic acids Scope, limitations of their reactions and their pharmaceutical applications. (6h).
5-Hydroxy acids. Scope, limitations of their reactions and their Pharmaceutical application (1hr)
6-Carboxylic acid derivatives (3hr)
i-acid chlorides ii- anhydrides
iii- esters iv- amides.
B- Applied courses.
1- Stereochemistry (18hr).
2- Stereochemistry of Carbohydrates. (8hr).

II- Practical Part (3 hours section /week, for 15 weeks):
- Identification of Amides (3hr)
- Identification of Aromatic amines. (3hr)
- Identification of Anilides (3hr)
- Identification of Amine salts. (3hr)
- Identification of Aromatic Sulphanilamides (3hr)
- Identification of Aromatic hydrocarbons (3hr)
- Identification of Halogenated compounds (3hr)
- Identification of Carbohydrates. (3hr)

- Determination of specific optical rotation and ee %. (3hr)
- Isolation and Identification of the liquid mixture. (6hr)
- Isolation and Identification of the Solid mixtures (9hr)



4.Pharmaceutical Organic Chemistry and Spectroscopy:
 

Code: 311/6
Credit hours (3+1)
Position: Second year, First Semester
I- Lectures: (3 hours lecture /week, for 15 weeks)
1) spectroscopy and elucidation of chemical structures
I. ultraviolet (4hr)
II. IR (3hr)
III. 1H-NMR, (4hr)
IV. 13C- NMR (1hr)
V. Mass spectroscopy (2hr)
2) Heterocylic chemistry (18hr)
I. Nomenclature:
a) Monocyclic
b) Fused Bicyclic and polycyclic with benezene and other heterocycles .
c) Five membered ring heterocycles with one heteroatom: (thiophenol, pyrrole, furane).
d) Six membered ring heterocycles with one heteroatom: (pyridine, pyran, thiin.
e) Fused benzene with 5 membered rings.
f) Fused benzene with 6 membered rings.
g) Monocycles (5, 6, 7 membered rings) with more than one heteroatoms, N, S, O.
3) Polynuclear aromatic compounds (7hr)
Naphthalene, anthracene, phenanthrene pyrene, C60.
4) Bio- amino acids; (Types, synthesis, IP values, Reactions, determination of sequence, solid phase synthesis of peptides). (7 hr)

II- Practical Part (3 hours section /week, for 15 weeks):
* Crystallization, & M.P. determination (3hr)
• Purification of liquids, & B. P. determination (3hr)
• Alcohols : - Identification , preparation of ethyl acetate & benzoic acid , IR characterization of ethanol , ethyl acetate , benzoic acid.
(6hr)
• Aldehydes & Ketones : - Identification, preparation of benzylidene aniline & phenyl hydrazone, IR characterization of starts & products.
(6hr)
* Phenols: - Identification, - Preparation of 2- naphthyl acetate, IR characterization of starts & products. Open discussion for illucidation of: H1 NMR spectra. (6hr)
Acids:- Identification , preparation of oxanilide & benzanilide, IR characterization of starts & products, Open discussion: H1 NMR spectra. (6hr)
Salts of carboxylic & phenolic acids :- Identification, Preparation of aspirin & tartar emectic, IR characterization of starts & products, Open discussion: H1 NMR spectra (3hr)
-Amides, amine, & amine salts: - Identification, Preparation of monophony urea& acetanilide, IR characterization of starts & products
- Open discussion:C13 NMR spectra. (3hr)
-Hydrocarbons : - Identification. Preparation of nitrobenzene , 2,4- trinitrotoluene, & 1-nitronaphthalene, IR characterization of starts & products, Solve problem in spectroscopy. (6hr)
- Preparation of pent acetyl glucose & osazone, IR characterization of starts & products (6hr)



5.Pharmaceutical Chemistry

Code: 461/6
Credit hours (3+1)
Position: Third year, First Semester
I- Lectures: (3 hours lecture /week, for 15 weeks)
I) Antibiotics
●b-Lactam antibiotics
●Tetracyclines
●Aminoglycosides
●Chloramphenicol
●Macrolides
II) Sulfonamides and Dihydrofolate Reductase Inhibitors with Antibacterial Action
●Short-, intermediate-, long-acting, and mixed sulfonamides
●Sulfonamides for ophthalmic infections
●Sulfonamides for burn therapy
●Sulfonamides for intestinal infections
III) Antineoplastic Drugs
●Alkylating Agents
Nitrogen mustards
Aziridines
Alkyl sulfonate derivatives
Nitrosoureas
Triazene derivatives
Hydrazine derivatives
● Antimetabolites
Dihydrofolate reductase inhibitors
Purine antagonists
Pyrimidine antagonists
● DNA-intercalating agents
● Antibiotics
● Antimitotic agents
● Hormones
● Enzymes
● Miscellaneous
IV) Antimalarials
●Quinoline derivatives
● 9-Aminoacridine derivatives
● Dihydrofolate reductase inhibitors
V) Antifungal Drugs
VI) Antiviral Activity
● FDA-approved Antiviral Agents for RNA Virus Infections
● Potential Anti-HIV-1 Agents
● Protease Inhibitors as Anti-HIV
VII) Antiinfective Agent
VIII) Antiprotozoal Agents
● Antiamebic Drugs
● Anthelmentic Drugs
IX) Antimycobacterial Agents
X) Leprosy (Hansen`s disease)
XI) Diuretics
● Carbonic Anhydrase Inhibitors
● Saluretics
Thiazides and related compounds
High-Ceiling or Loop saluretics
● Potassium-Sparing Diuretics
XII) Oral Antidiabetic Drugs
XIII) Diagnostic Agents
XIV) Immunostimulants.

II- Practical Part (3 hours section /week, for 15 weeks):
1- : General instructions, sources of impurities in pharmaceuticals, official methods of control, difficulties, limit test for chloride and sulfate by E.P.and B.P..
2- Limit test for chloride and sulfate by E.P.and B.P( practical) .
3- Limit test for iron by E.P.and B.P.
4- Limit test for lead by E.P.and B.P., calculations, limit test for arsenic by E.P.and B.P.
5- Limit test for heavy metals in presence and absence of lead by E.P.and B.P.,limit test for lead in potassium antimony tartarete sample .
6- Introduction to IR spectroscopy, tests for purity ( revision) .
7- Introduction to NMR spectroscopy, IR charts, tests for purity ( revision).
8- IR and NMR spectra, tests for purity (revision ).
9- Identity tests, revision of IR and NMR spectra.
10-15: Drug Identity tests.




6.DRUG DESIGN:

Code: 412/6
Credit hours (3+1)
Position: Third year, Second Semester

I- Lectures: (3 hours lecture /week, for 15 weeks)
Part I: (25 hr)
- Adrenergic agents., Cardiovascular drugs, Antihypertensive agents.
- Antiarrhythmic agents, Antianginal agents, Cardiotonics, Antihyperlipidemic agents.
- Anticoagulants.
- Central nervous system stimulants, Analeptics, Sympathomimetic agents. Antidepressants.
- CNS Depressants.General Anesthetics.Sedative-Hypnotics.
- Anxiolytics. Centrally Acting Skeletal Muscle relaxants, Anticonvulsants, Antipsychotics.
- Cholinergics, Anticholinergics, Muscarinic agonists. Reversible inhibitors of AchE, Irreversible inhibitors of AChE, Organophosphate antidote, Muscarinic antagonists.
- Antiparkinsonism drugs.
- Local anesthetics.
- Antiallergenic and antiulcer drugs, Histamine H1-receptor antagonists, Histamine H2 receptor antagonists and antiulcer drugs, Histamine H3 receptor prototypes.
Part II: Drug Design:
Non-computational drug design: (10 hr)
- Improvement the binding interactions between a drug and its target:
- Finding and molecular manipulation of a lead compound.
- Drug action at receptors., The steric features of the drugs.,
- Improvement the phamacokinetic properties of the drugs.
- Quantitative structure activity relationship (2D and 3D).
- Prodrugs: Utility of prodrugs; Bioprecursor; Hard and soft drugs.
Computer aided drug design: (6 hr)
- Concept of computer visualization and molecular modeling.
- Pharmacophores.
- Features and complementary active sites for the pharmacophoric elements.
- Steps of indirect computer-aided drug design using catalyst modules.
- Steps of indirect computer-aided drug design using cerius modules.
Part II: Drug Metabolism: (3hr)
-Phase 1: Oxidation; Reduction; Hydrolysis.
-Phase 2: Glucuronide formation; Sulfate formation; Methylation;
Acylation; Glycine, glutamine and glutathione conjugates.

II- Practical Part (3 hours section /week, for 15 weeks):
Section I: Introduction about pharmacopoeia and methods of drug analysis (theoretical).
Section II: Methods of drug analysis (theoretical); Analysis of Chlor-promazine and Sedative mixture.
Section III: Methods of drug analysis (theoretical); Analysis of Nifedipine and Chloralhydrate.
Section IV: Methods of drug analysis (theoretical); Analysis of Aluminium and Mgnesia Oral Suspension and Oral Rehydran Salts.
Section V: Methods of drug analysis (theoretical); Analysis of Fenterol Hydrochloride and Compound Sodium Lactate (intravenous infusion).
Section VI: Methods of drug analysis (theoretical); Analysis of Astemazole and Haemodialysis Solution.
Section VII: Methods of drug analysis (theoretical); Analysis of Aminophylline and Meglumine Diatrizoate Injection.
Section VIII: Methods of drug analysis (theoretical); Analysis of Anticoagulant acid-Citrate-Glucose Solution and Magnesium Sulphate Paste.
Sections IX -XV: Computer-aided drug design





7.Pharmaceutical Chemistry

Code: 561/6
Credit hours (2+1)
Position: Third year, First Semester
I- Lectures: (2 hours lecture /week, for 15 weeks)
Vitamins: (6 hr)
Fat-soluble vitamins (A, D, E, K), Water-soluble vitamins, (C, B1,B2,B3,B5,B6, B12 etc..)
Hormones: (10 hr)
- Thyroid Hormones, Therapeutic Agents used for treatment of Hypothyroidism, Therapeutic Agents used for treatment of Hyperthyroidism.
- Corticosteroids, Glucocorticoids, Mineralocorticoids
- Sex Hormones : Mal Sex Hormones, Androgen, Antiandrogens.
Female Sex Hormones ; Estrogens, Antiestrogens,
Progestins , Antiprogestins.
-Peptide Hormones, Pituitary and Hypothalamic H, Peptide Structure,
Determination Peptide Synthesis
-Opioid Analgesics (2hr)
- Non- Opioid Analgesics, (2hr)
- Non-steroidal Anti- inflammatory Drugs (6hr)
- Aging and Antiaging Therapies: (6hr)
Causes of Aging, Diseases Associated with Aging, Antiaging
Therapies (Antioxidants, Nootropic Drugs, Hormonal Therapies,
Neurodegenerative Therapies, Antiglycating Therapies, Lipofuscin
Remover).

II- Practical Part (3 hours section /week, for 15 weeks):
1- Analysis of non – steroidal anti-inflammatory Drugs:
• Aspirin powder and tablet,
• Aloxiprin tablet,
• Ibuprofen tablets
• Dipyrone tablets
• Indomethacin capsules
• Paracetamol poweder x tablet,

2- Analysis of Vitamins :
• Ascorbic acid injection & tablet,
• Calcium gluconoascorbate solution
• Thiamine hydrochloride
• Menadione
• Vitamin A
• Folic Acid
3- Analysis of Hormones:
• Thyroxine tablets
• Ethinylestradiol tablet
• Progrsterone injection

4- Analysis Pharmaceutical Preparations:
• Eye lotion
• Alkaline nasal wash
• Anti corn paint