Mohamed Abdel Hamid Ismail

CURRICULUM VITAE

Mohamed Abdel Hamid

Ismail (Ph.D)

Professor in the Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain - Shams University, Abbassia – El-Khaleffa El – Ma`amoon street,

Tel: Mobile: (002012)3269674, Home: (00202)2560904

1- Bachelor in Pharmaceutical Sciences, Faculty of Pharmacy, Cairo University, May 1975.

2- Master Science degree in Pharmaceutical Sciences(Organic Chemistry), Faculty of Pharmacy, Cairo University December,1980.

3- Doctor of Philosophy in Pharmaceutical Sciences(Organic Chemistry), Faculty of Pharmacy, Cairo University, April, 1985.

4- Assistant Professor, in Pharmaceutical Sciences (Organic Chemistry), Faculty of Pharmacy, Cairo University, January, 1993.

5- Professor in Pharmaceutical Sciences (Pharmaceutical Chemistry), Faculty of Pharmacy, Ain Shams University, December, 2000.

1- Instructor of Organic Chemistry , in Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 1975.

2- Assistant Lecture of Organic Chemistry, in Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 1980.

3- Lecturer of Organic Chemistry, in Organic Chemistry Department, Faculty of Pharmacy, Cairo University1985,.

4- Associate (Assistant) Professor of Organic Chemistry, in Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 1993.

5- Associate (Assistant) Professor of Pharmaceutical Organic Chemistry, in Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain- Shams University, 1997.

6- Acting Head of Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain-Shams University, From August 23, 1997 - April 2001.

7- Professor of Pharmaceutical Organic Chemistry, in Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain- Shams University, since Jan, 2001 till now.

8- Head of Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain-Shams University, April, 2001 till November, 2002.

9- Vice Dean of Faculty of Pharmacy, Ain-Shams University, from August, 1, 2001 till August, 1, 2004.

10- Reselected Vice Dean of Faculty of Pharmacy, Ain-Shams University, from August, 1, 2004 till now.

Teaching of Courses of Organic Chemistry & Pharmaceutical Chemistry, Forensic Chemistry, Drug Design, Computer Aided Drug Design, for undergraduates and Postgraduates students at the following Faculties of Pharmacy:

1- Association in IXX^th , XXII^th ,XXIV^th ,XXV^th , XXVI^th, Phamarmaceutical Sciences Conferences helded at Cairo City, in 1980, 1992, 1994, 1996, 1998, respectively.

2- Association in 5^th and 6^th IBN -SINA International Conferences on Pure and Applied Heterocyclic Chemistry at Cairo 1995 and 1997, 2000.

3- Association in 5^th International Symposium on Carbanion Chemistry (ISCC-5) , August, 1998, at Sendai City, Tohoku University, Japan.(By research no. 18).

4- Member of Workshop of Computer Drug Design for Pharmacophore Generation using Catalyst Softwares Modules, Organized by the International Accelrys Company and hold at Cambridge/UK in November 2- 25, 2001. (This was followed by establishing the computer aided drug design laboratory which was done by me). Then sharing with Mrs. Tien Luu (the main Trainer of Accelrys Ltd company) to train all the staff members of the pharmaceutical chemistry department of Faculty of Pharmacy, Ain Shams University for the use of Catalyst and Cerius 2 Modules in Drug Design.

5- Invited supervisor in the Creative Conference of Arabic students at Bayrut, October, 2002.

6- Invited speaker in the Conference of the international pharmaceutical Science conferences which were hold at Tripoli, April, 2003 and at Beghazy, May, 2004.

7- Main organizer of TWO WORKSHOPS in Computer-Aided Drug Design which was hold at Faculty of Pharmacy, Ain Shams University, (At March, 2002 and April, 2003), for training staff members of pharmaceutical chemistry from all the Egyptian universities to use this high technology in drug design. The number of shared and participated staff members in these workshops reached 28 + 36, including professors , assistant professors, lecturers and instructors.

8- Inviting lecturer in 9^th IBN -SINA International Conferences on Pure and Applied Heterocyclic Chemistry at Sharm El-Sheek City, Dec., 2004.

1- Reviewer for the research projects of the National Research Center of Egypt.

2- Member of the team of the scientific committee of the 9^th IBN-SINA international conference, for organization, reviewing, ………etc.

3- Selected as a Reviewer for the CANADIAN JOURNAL OF CHEMISTRY, which is issuing by the CANADIAN QUEEN UNIVERSITY.

1) Establishment of computer aided drug design lab (constructed from silicon graphic server computer machines, connecting intra-network, and softwares package of accelrys molecular modeling modules), at faculty of pharmacy, ain shams university,

2) Establishment of the curricula of molecular modeling and computer drug design for Undergraduate and Postgraduate students.

1- Sharing in the establishment of the newly founded building of Faculty of pharmacy Ain Shams University since 1997 till now.

2- Association in all the meetings of Faculty of pharmacy Council, Ain Shams University.

3- Participates in all the Vice-Deans council meeting of Ain Shams University which help in organizing and developing teaching programs.

1- Member of the scientific grant at Tohoku University for 3 months (May,1 till August 5, 1998). This grant was fulfilled at the scholarship of Professor Masataka Ihara (One of the most important professor in Japan who is interested in the synthesis of natural products). His email:< mihara@mail.pharm.tohoku.ac.jpv >.

2- Member of the workshop meeting in COMPUTER AIDED DRUG DESIGN, Pharmacophore Generation, using Catalyst, Accelrys Modules, which was held at CAMBRIDGE, UK, November 2- 25, 2001.

Acquiring the Ain Shams University award for the EXCELLENT RESEARCHES in the field of PHARMACEUTICAL CHEMISTRY at Jun, 28, 1999.

1- Supervision On M.S. Theses discussed at 1992 in Organic Chemistry Department, Faculty of Pharmacy, Cairo University.

2- Supervision On Ph.D. Theses discussed in 5/23/1987 at Organic Chemistry Department, Faculty of Pharmacy, Cairo University.

3- Supervision On Ms.D. Theses discussed in April 2001, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University.

4- Supervision On Ms.D. Theses discussed in Jan, 2002, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University.

5- Supervision On Ms.D. Theses discussed in July, 2004, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University.

6- Supervision On TWO Ms.D. Theses, the 1^st was discussed at 5/1/2005 and the 2^nd was discussed at 3/2/2005, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University.

7- Supervision on 8 Ms.D. Theses and 2 Ph.D Theses in Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain -Shams University, National Research Center of Egypt, Institute of Egyptian Nuclear Energy Organization and still in work till now. All are in the filled of Molecular Modelling and synthesis Antihypertensive, Ant-diabetic and anti-inflammatory agents.

1- Principle investigator for two projects for the Discovery, Synthesis and Production of Egyptian Drug for treating hypertension in Human, funded by Ain Shams University.

2- Sharing in presenting ICTP and TEMPUS projects for the development of education at Faculty of Pharmacy, Ain Shams University.

i- Matthew H. Todd <M.H.Todd@qmul.ac.uk> (Professor of Synthetic Chemistry, Queen Marry University of London, Mile End Road, London, El 4NS UK.

ii- Stewart Barker School of Biological Sciences, Queen Mary, University of London, EI 4NSUK.

Such collaboration was granted by Queen Marry University of London for my students Rabab Tobar to gain her Master Degree in the molecular modeling, drug design, synthesis of various new antihypertensive agents. Dr. Todd and Dr. Barker agreed to collaborate this work in their laboratories financed by Queen Marry University. A paper of this work is in press now.

Acquiring the intellectual properties of two Molecules, one as antihypertensive agent and the second as anti-tumor agent, registered at the intellectual properties section of the Egyptian Academy of Scientific Researches.

Aliphatic, Aromatic, Heterocycles, Polynuclear, Polymers, Spectroscopy, Stereochemistry, Asymmetric Synthesis,….etc. Practical identification and synthesis of various organic molecules especially drugs.

Teaching of Antimetabolites, Anti-infective agents, antiviral agents (especially Anti-HIV-1, anti-Hepatitis B & C), Anti-Cancer, antibiotics, CNS depressants and stimulants, Cardiovascular and antihypertensive agents, Antidiabetics, Anti-cholesterols, Drug Metabolism, Non-Computational and Computational molecular modeling Drug Design. The practical part involves teaching the different methods of drugs analysis, either by titration or by spectrophotometry. Also, it involves teaching the practical molecular modeling and design of new Chemical entities using Catalyst and Cerius 2 softwares packages (of Accelrys) which are running in SGI-fuel computer workstation under the commands of UNIX system.

Synthetic Organic and Pharmaceutical Chemistry, which are rationalized by Molecular modeling to design new molecules, Asymmetric Synthesis. The main topics are in hydantoins, Coumarines, quinazolines, pyrrole derivatives, imidazoquinazolines, Biphenyl-tetrazoles and Arylpiperazines linked to various heterocycles.

مجمل الإنتاج العلمي

القيام بإجراء ونشر عديد من الابحاث تشمل تشييد عــديد من المركبات الجديدة من مشتقات الحلقات الغير متجانسة والتي لها تأثيرات بيولوجية وصيدلية فعالة.

1) Ligand Design and Synthesis of New Imidazo[5,1-b]quinazoline Derivatives as a₁- Adrenoceptor Agonists and Antagonists

Mohamed A. H. Ismail ^a,*, Mohamed N. Y. Aboul-Enein^b,, Khaled A. M. Abouzid^a and Rabah A. Serya^a

2) Design and Synthesis of New Tetrazolyl- and Carboxy-biphenylylmethyl-quinazoline Derivatives asd Angiotensin II AT1 Receptor Antagonists.

Mohamed A. H. Ismail, Mathew H. Todd, Stewart Barker, Dalal A. El Ella, Khalid A. M. Abouzid and Rabab A. Tobar.

3) Computer Aided-Drug Desigyn qand Synthesis of certain Thiazolidines As Analgesic And Anti-inflammatory Agents.

Mahmoud A. Elgendy, Nadia M. Mahfouz, Gamal Eldin S. Alkamary, Ahmed M. Shaheen, Mohamed A. H. Ismail, Awaad A. R. Salama

4) Molecular Design and Synthesis of Certain Thienopyrimidines as potential a₁ Antagonists.

Mohammed A Ismail , Dalal A Abou-Ella , Kaled A.M.Abouzid , Emann E Al bastwessy , Sahar B A Kandil and Mohei Ellithey.

5) Synthesis of Certain 1-Alkyl and 1-benzyl 2,4-Dimethyl-2-(4-methoxybenzyl)-Pyrrolidin-3-ols and their Substituted Benzoates of Anticonvulsant, neuroleptic and analgesic Profile

Mohaamed Nabil Y. Aboul-Enein, Mohamed A. H. Ismail, Yousreya A. Maklad and Nasser S. Mohamed

6) Synthesis of Various Certain 5,6,7,8-Tetrahydrobenzo[b]thienopyrimi-dines Fused

with Various Heterocyclic Ring Systems As Potential Antihypertensive Agents.

Mohamed Abdel-Hamid Ismail, Mohaamed Nabil Y. Aboul-Enein, Khaled A. M. Abouzid, and Sahar B.A. Kandil

7) New Method for Preparing Novel 3-Alkyl-2-thioxo-1,3-diazaspiro[4.5]-decan-4-one and 4-Alkylimino-3-oxa-1-azaspiro[4.5]decan-2-thione Derivatives Having Potential Biological Activities

8) Synthesis and Evaluation for Potential Antihypertensive Activity of a Series of Imid- azolinone Oximes and Cyclohexanespiro-8-imidazo[5,1-c]-1,2,4-oxadiazines

Mohamed Abdel-Hamid Ismail, Khaled Abouzid, Awatef E. Farag and Amani E. Khalifa³ ,

9) Macrocyclic Compounds: Synthesis of Various 6,15-Dithia2,3,8 ,11,12,17,19, 20- octa-azatricyclo[14.2.1.1^7,16]eicosa-1,7(20),10,16-(19)-tetraene-4,13-dione Derivatives Having Potential Antitumor Activity

10) Asymmetric Total Synthesis of (+)-Equilenin Utilizing Two Types of Cascade Ring Expansion Reaction of Small Ring Systems

Masahiro Yoshida, Mohamed Abdel-Hamid Ismail, Hideo Nemmoto and Masstaka IHARA^*

11) Novel Method for the Synthesis of Chiral 4-Aryl-g- buterolactones Via Cascade Assymetric Epoxidation-Ring Expantion-Baeyer-Villegar Reaction of Cyclopropylidene Derivatives.

Masahiro Yoshida, Mohamed Abdel-Hamid Ismail, Hideo Nemmoto and Masstaka IHARA^*

12) Synthesis of Various Imidazo[5,1-c][1,2,4]triazole Derivatives Having Potential Biological Activities

13) Indazole Derivatives (Part III): Synthesis of Pyrazolo[1,2-a]indazole-1,9-dione, [1,2,4]Triazino[1,2-a] indazole-1,10-dione, 3-(Indazol-1-yl)propionic Acid Amides and Hydrazides Possessing Potential Biological Activities

14) Indazole Derivatives (Part II): Synthesis of Novel [1,2,4]Triazolo[1,2-a]indazoles, [1,2,4]Triazino [1,2-a]indazoles and [1,2,4]Triazepino[1,2-a]indazoles of Potential Biological Activity.

M. M. Badran, Mohamed Abdel Hamid Ismail, K. Youssef, N. Abdu and M. Abdel-Hakeem.

15) Synthesis of Certain Pyrazolo[1,2-a]indazole-1,3,9-trione Derivatives of Potential Biological Interest: Part I.

M. M. Badran, Mohamed Abdel Hamid Ismail, K. Youssef, N. Abdu and M. Abdel-Hakeem.

1) Hydantoins and Thiohydantoin Derivatives as Potential antimicrobial Agents. Part I,

2) Hydantoins and Thiohydantoin Derivatives as Potential antimicrobial Agents. Part II,

Khadiga M. Ghoneim, Farag el-Telbany and Mohamed Abdel-Hamid Ismail, Egypt.

3) A simple One-Step Synthesis of Some New 4(6-Substituted Benzothiazol-2-yl)-1-Thia-4-Azaspiro[5:4]Decan-3-one Derivatives as potential Antimicrobial agents ;

Farag El-Telbany, Mohamed Essaway, Mohamed Abdel-Hamid Ismail, and Talaat El-kersh;

4) Synthesis of Some derivatives of 3- Acetylindole of potential Biological Activity,

5) Synthesis of 2-(1,3,4-Oxadiazol-2yl)methylthio and 2-[2-(Aroylhydrazino)-2-oxoethylthio]imidazolinone Derivatives of Expected Antimicrobial Activities.;

6) Synthesis of 2-[3-substituted amino-2-hydroxypropylthio]-1-methyl-5-oxo-2-Imidazoline derivatives of Pharmaceutical Interest. A new method for Desulphurization of 2-thiohydantoins;

7) Synthesis of Novel Furan containing DNA Minor grove Binding Oligopeptides related to Netropsin of pharmaceutical Interst;

8) Synthesis of some Novel 4(3H)Quinozolinones as potential antimicrobial agents;

9) Coumarin Derivatives (part I). Synthesis of some thiadiazolyl, Oxadiazolyl and triazolylcoumarines of Biological interst;

10) Coumarin Derivatives (part II). Synthesis and antimicrobial activity of certain sulphonamide, sulphonylhydrazine and sulphonyl azide Derivatives of 4-methyl-7-hydroxy coumarin;