Research

Research is a major activity in the department with nine ongoing projects. Areas of special emphasis include:

a. Environmental Toxicology supervised by Dr. Ashraf B. Abdel-Naim.
b. Neuropsychopharmacology supervised by Dr. Amani E. Khalifa.
c. Cancer Chemotherapy supervised by Dr. Ebtehal El-Demerdash Zaki Morsi.

Departmental Publications

1. In vitro activation of dibromoacetonitrile to cyanide: role of xanthine oxidase. Mohamadin AM, Abdel-Naim AB. Arch Toxicol 77(2): 86-93 (2003).

2. Polymorphic metabolizing genes and susceptibility to atherosclerosis among cigarette smokers. Salama SA, Au WW, Hunter GC, Sheahan RG, Badary OA, Abdel-Naim AB, Hamada FMA. Environ Mol Mutagen 40: 153 –160 (2002).

3. Potential protective effect of melatonin against dibromoacetonitrile-induced oxidative stress in mouse stomach. Abdel-Wahab MH, Arafa HMM, El-Mahdy MA, Abdel-Naim AB. Pharmacol Res 46(3): 287-293. (2002).

4. Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain. Ghoneim AI, Abdel-Naim AB, Khalifa AE, El-Denshary ES. Pharmacol Res 46(3): 273-279 (2002).


5. Hypericum perforatum as a nootropic drug: enhancement of retrieval memory of a passive avoidance conditioning paradigm in mice. Khalifa A.E.. Journal of Ethnopharmacology 76 (1): 49-57 (2001).

6. Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain. Abd El-Gawad H.M. and Khalifa AE.. Pharmacological Research 43 (3): 257-263.(2001).


7. Probucol and liver efficiency during hepatocarcinogenesis. El-Demerdash E.; El-Denshary E.S.; Khalifa A.E.; El-Didi M.; Al-Gharabli N. and Osman A.M., Anticancer Res.,21 (3A): 1572.(2001).


8. Differential alteration of cisplatin cytotoxicity and myelotoxicity by the paclitaxel vehicle cremophor EL. Badary OA, Abdel-Naim AB, Khalifa AE, Hamada FMA. Arch Pharmacol 361: 339-344 (2000).

9. The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats. Badary OA, Abdel-Naim AB, Abdel-Wahab MH, Hamada FMA. Toxicology 143: 219-226 (2000).


10. Prevention of cisplatin-induced nephrotoxicity by methimazole. Osman A.M.; El-Demerdash E.; El-Sayed E.M.; Al-Hyder A.; El-Didi E.; Attia A.S. and Hamada F.M.A., Pharmacol. Res., 41 (1): 115-121.(2000)

11. Chloroacetonitrile-induced oxidative stress and toxicity in rat gastric epithelial cells. Mohamadin AM, Abdel-Naim AB. Pharmacol Res 40 (4): 377-383 (1999).

12. Protective effects of vitamin E and probucol against gentamicin-induced nephrotoxicity. Abdel-Naim AB, Abd El-Wahab HM, Attia FF. Pharmocol Res 40(2):183-187 (1999).

13. Renal bioactivation of acrylonitrile: in vitro studies. Mostafa AM, Abdel-Naim AB, Abo-Salem O, Abdel-Aziz AH, Hamada FMA. Pharmocol Res 40(2): 195-200 (1999).


14. Possible neuroprotective effects of melatonin against ischemia/reperfusion insult in rat brain. Seif-El-Nasr M., L.G. Mahran, H.S. Al-Abhar, A.E. Khalifa, E.S.M. El-Denshary. Medical Science Research, 27, 605-608. (1999).

15. In Vitro testicular bioactivation of acrylonitrile (VCN). Abdel-Aziz AH, Hamada FMA, Abdel-Naim AB, Ahmed AE. Pharmocol Res 35(2): 129-134 (1997)